So Morishita

Quantitative Modeling of Insulin Signaling Reveals Mechanisms of Insulin Resistance in Obese Mice

The paper develops mathematical models of insulin signaling in obese mice to show that changes in protein expression levels explain signal attenuation and identify mechanisms of selective insulin resistance.

Comparable affinity of RabGDIα for GTP- and GDP-bound forms of Rab7 supports a four-state transition model for Rab7 subcellular localization

The paper investigates Rab7's subcellular localization by showing RabGDIα interacts with both GTP- and GDP-bound forms of Rab7, supporting a four-state transition model for Rab7 function.