Hiroyuki Kubota

Quantitative Modeling of Insulin Signaling Reveals Mechanisms of Insulin Resistance in Obese Mice

The paper develops mathematical models of insulin signaling in obese mice to show that changes in protein expression levels explain signal attenuation and identify mechanisms of selective insulin resistance.

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

This study uses multiomic analysis of skeletal muscle in obese and healthy mice to reveal differences in metabolic regulation by metabolites and genes after glucose administration.

Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism

This paper introduces OMELET, a method to infer metabolic flux from multi-omic data, and applies it to identify obesity-associated dysregulation in liver glucose metabolism.

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

The paper develops a mathematical model to predict an optimal glucose ingestion pattern that minimizes peak blood glucose levels in humans, validated through experimental testing.

Trans-omic analysis reveals allosteric and gene regulation-axes for altered glucose-responsive liver metabolism associated with obesity

The paper analyzes trans-omic data from healthy and obese mice to reveal that glucose-responsive liver metabolism is regulated by rapid changes in metabolites and gene expression in the healthy state, and by slow transcriptional regulation in the obese state.

Single-cell information analysis reveals small intra- and large intercellular variations increase cellular information capacity

The paper shows that small intracellular and large intercellular variations enhance information transmission, enabling precise tissue function control.

Bidirectional Changes Of Hepatic And Peripheral Insulin Clearance Characterize Abnormal Temporal Patterns Of Serum Insulin Concentration In Diabetic Subjects

The paper develops a mathematical model to show that bidirectional changes in hepatic and peripheral insulin clearance explain abnormal serum insulin concentration patterns in diabetic subjects.

System Identification Using Compressed Sensing Reveals Signaling-Decoding System By Gene Expression

The paper develops a system identification method using compressed sensing to analyze signaling-decoding systems with different time scales, revealing gene expression responses to signaling activation.

Trans-omic analysis reveals fed and fasting insulin signal across phosphoproteome, transcriptome, and metabolome

The paper constructs a trans-omic network of insulin action using phosphoproteomic, transcriptomic, and metabolomic data to identify fed and fasting insulin signals.