Allosteric modulation of TIA-1 phase separation by double serine phosphorylation
Alejandro Velázquez‐Cruz, Laura Corrales‐Guerrero, Ana Belén Uceda, Emanuela Tumini, Sofía M. García-Mauriño, Saboora Waris, Rafael L. Giner‐Arroyo, Fionna E. Loughlin, Rafael Fernández‐Chacón, Jacqueline A. Wilce, Miguel Ángel De la Rosa, Irene Díaz‐Moreno
This study investigates how double serine phosphorylation in TIA-1 affects its phase separation and structure, revealing its role in stress granule formation and disease-related mutations.
bioRxiv · Aug 21, 2025 · PreprintBiophysics