Author

Rafael Fernández‐Chacón

Biomedical Research Networking Center on Neurodegenerative DiseasesORCID 0000-0002-9845-9885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Nozha BorjiniiD· 2 shared Alberto PascualiD· 1 shared Alejandro Collado-SoléiD· 1 shared Alejandro Velázquez‐CruziD· 1 shared Alexandra BarrancoiD· 1 shared An JacobsiD· 1 shared Ana Belén UcedaiD· 1 shared Ángela Lavado-RoldániD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Nozha BorjiniORCID

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Author profile →

3 papers

Recent·Most cited

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

Alejandro Collado-Solé, Nozha Borjini, Jing Zhai, Gonzalo Soria-Alcaide, Cintia Folgueira, Francisco Ruíz-Pino, Celia García Vilela, Víctor López, Yassine Zouaghi, An Jacobs, Bella Mora-Romero, Alexandra Barranco, Guillermo Yoldi, Karine Rizzoti, Guadalupe Sabio, , Eva González‐Suárez

The paper shows that microglia use Rank signaling to regulate GnRH function and the HPG axis, leading to hypogonadotropic hypogonadism when disrupted.

bioRxiv · Feb 18, 2026 · PreprintCell Biology

Allosteric modulation of TIA-1 phase separation by double serine phosphorylation

Alejandro Velázquez‐Cruz, Laura Corrales‐Guerrero, Ana Belén Uceda, Emanuela Tumini, Sofía M. García-Mauriño, Saboora Waris, Rafael L. Giner‐Arroyo, Fionna E. Loughlin, Rafael Fernández‐Chacón, Jacqueline A. Wilce, Miguel Ángel De la Rosa, Irene Díaz‐Moreno

This study investigates how double serine phosphorylation in TIA-1 affects its phase separation and structure, revealing its role in stress granule formation and disease-related mutations.

bioRxiv · Aug 21, 2025 · PreprintBiophysics

Neuronal lipofuscinosis caused by Kufs disease/CLN4 DNAJC5 mutations but not by a CSPα/DNAJC5 deficiency

Santiago López-Begines, Ángela Lavado-Roldán, Cristina Mesa-Cruz, Fabiola Mavillard, Nozha Borjini, Vera I. Wiersma, Carolina Aguado, Rafael Luján, Wiep Scheper, José Luis Nieto-González, Rafael Fernández‐Chacón

This study creates mouse models overexpressing mutant CSP/DNAJC5 and shows they develop neuronal lipofuscinosis and GRODs, while CSP/DNAJC5 deficiency does not.

bioRxiv · May 10, 2023 · PreprintNeuroscience