Author

Sofia Cassidento

UConn Health

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Molecular Biology· 1

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Approach:experimental assay· 1

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Arthur GünzliD· 1 shared Bing HaoiD· 1 shared Kazuya MachidaiD· 1 shared Nuala PetermaniD· 1 shared Priyanka Rattan· 1 shared

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2026-2026 · peak 1/yr

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1 paper

Recent·Most cited

SF3B1 phosphorylation is an evolutionarily conserved step in spliceosome activation carried out by the divergent, OTS964-insensitive kinase CRK9 in trypanosomes

Kazuya Machida, Priyanka Rattan, Sofia Cassidento, Nuala Peterman, Bing Hao, Arthur Günzl

The paper shows that CRK9, a trypanosome kinase, phosphorylates SF3B1 TP motifs to activate the spliceosome, conserving a function previously known in CDK11, and is insensitive to OTS964.

Nucleic Acids Research · May 15, 2026Peer-reviewedMolecular Biology