Author

Kazuya Machida

UConn HealthORCID 0009-0000-2140-1354Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alekhya Abhiram KandooriD· 1 shared Anny Carolline Silva OliveiraiD· 1 shared Arthur GünzliD· 1 shared Bing HaoiD· 1 shared Blagoy BlagoeviD· 1 shared Kristen M. NaegleiD· 1 shared Nuala PetermaniD· 1 shared Priyanka Rattan· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperSystems Biology

Alekhya Abhiram KandoorORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintAug 21, 2026

SpY-C: Supervised Learning of Phosphopeptide Sequence Constraints Enables Global Prediction of SH2 Domain Binding

Alekhya Abhiram Kandoor, Anny Carolline Silva Oliveira, Kazuya Machida…·Kristen M. Naegle

SpY-C classifies phosphopeptide sites as potential SH2 domain binders using supervised learning, improving annotation of pY function and informing downstream machine learning approaches.

DOI 10.64898/2026.08.18.744962

humanproteomics

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Molecular BiologyNucleic Acids ResearchPeer-reviewedMay 15, 2026

SF3B1 phosphorylation is an evolutionarily conserved step in spliceosome activation carried out by the divergent, OTS964-insensitive kinase CRK9 in trypanosomes

Kazuya Machida, Priyanka Rattan, Sofia Cassidento…·Arthur Günzl

The paper shows that CRK9, a trypanosome kinase, phosphorylates SF3B1 TP motifs to activate the spliceosome, conserving a function previously known in CDK11, and is insensitive to OTS964.

DOI 10.1093/nar/gkag541

experimental assay

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