Bing Hao

The paper shows that CRK9, a trypanosome kinase, phosphorylates SF3B1 TP motifs to activate the spliceosome, conserving a function previously known in CDK11, and is insensitive to OTS964.

This study investigates the assembly mechanism of the USP7/MAGEL2 complex and identifies mutations that disrupt its formation, linking it to neurodevelopmental diseases.

This study identifies a novel nucleic acid-binding module, PXL, in PML-1 and shows it binds G-rich RNA/DNA and modulates the transcriptome.

This study identifies PTBP1 as a key regulator of endothelial dysfunction in cardiac allograft vasculopathy, showing its deletion reduces fibrosis and immune activation in mouse models.

The paper identifies loss of nuclear TDP-43 in endothelial cells as a mediator of BBB signaling pathway dysfunction in neurodegenerative diseases using inCITE-seq.