PROTAC-Driven Protective Therapy increases the therapeutic window of anticancer drugs
Lucía Simón-Carrasco, Soledad Raya, Elena Pietrini, Manuel Luque-Perez, Marta del Rio Oliva, Ivan Rosado, Andres Joaquin Lopez-Contreras
This paper introduces PROTAC-Driven Protective Therapy (PDPT) to reduce toxicity of anticancer drugs by degrading proteins involved in drug-induced toxicity, showing protection of healthy cells and efficacy in TP53-mutant cancers.
bioRxiv · Jan 13, 2026 · PreprintCancer Biology