Marta del Rio Oliva

PROTAC-Driven Protective Therapy increases the therapeutic window of anticancer drugs

This paper introduces PROTAC-Driven Protective Therapy (PDPT) to reduce toxicity of anticancer drugs by degrading proteins involved in drug-induced toxicity, showing protection of healthy cells and efficacy in TP53-mutant cancers.

HMCES corrupts replication fork stability during base excision repair in homologous recombination deficient cells

The paper shows HMCES causes replication fork instability in HRD cells during BER of 5hmdC-derived lesions, leading to chromosomal damage and cell death.