Fibrin-containing Hydrogels Regulate Human Astrocyte State and Neuronal Reprogramming
Thomas Distler, Katherina Konrad Daga, Martina Bürkle, Soledad Sepúlveda, Kristian Franze, Magdalena Götz, Giacomo Masserdotti
This study shows that fibrin-containing hydrogels influence human astrocyte states and their ability to reprogram into neurons, with 3D-Fibrin promoting neuronal conversion while 3D-FAR induces an inflammatory state that hinders reprogramming.
bioRxiv · Nov 5, 2025 · PreprintNeuroscience