Giacomo Masserdotti

This study shows that fibrin-containing hydrogels influence human astrocyte states and their ability to reprogram into neurons, with 3D-Fibrin promoting neuronal conversion while 3D-FAR induces an inflammatory state that hinders reprogramming.

The paper shows that Hmgb2 enhances astrocyte-to-neuron conversion by regulating chromatin accessibility of neuronal maturation genes in response to growth factors.