Kristian Franze

This study visualizes actin conformation dynamics in CTLs and shows they precede force generation during immune synapse formation.

The paper shows that mechanical signals regulate long-range chemical signaling in the developing Xenopus brain by modulating tissue stiffness and expression of guidance cues.

This study shows that fibrin-containing hydrogels influence human astrocyte states and their ability to reprogram into neurons, with 3D-Fibrin promoting neuronal conversion while 3D-FAR induces an inflammatory state that hinders reprogramming.

This study examines how patient-derived glioblastoma cells from different tumor regions respond to adhesion and metabolic inhibitors, showing heterogeneity in drug sensitivity linked to migration and adhesion properties.

This study introduces Glycan Atlassing, a method using DNA-tagged lectin labeling and metabolic oligosaccharide engineering to map glycocalyx architecture at nanometer resolution, revealing spatial relationships that reflect cellular state.

This study investigates how measurement force, speed, post-mortem time, and temperature affect the grey-to-white-matter elasticity ratio in spinal cord tissue, identifying parameter-dependent variations.

Dedifferentiated fibroblasts sequentially induce and resolve neutrophil-driven inflammation through cytokine release to facilitate axon regeneration after spinal cord injury in zebrafish.

This study identifies how tissue mechanics and hyaluronic acid regulate digit tip regeneration by modulating ECM composition and cell behavior.

This study shows that substrate stiffness affects neuronal maturation by regulating Piezo1-mediated TTR activity, delaying synapse formation and electrical maturation.

The paper investigates how mutations in the FUS protein affect axonal cytoskeletal organisation in ALS/FTD models, finding reduced actin density and axonal branch complexity.

This study shows that tissue stiffness regulates Eph/ephrin signalling in the Xenopus optic pathway, with mechanical gradients correlating with EphB and ephrinB expression patterns.

This study investigates how mechanical properties of neural tissue change after injury, finding that PNS tissue stiffens while CNS tissue softens, potentially influencing regeneration.

This study shows that Plakoglobin regulates naive pluripotency in mouse ESCs through mechanosensitivity, with expression specific to the blastocyst stage in human and mouse embryos.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

The paper models axon bundle migration in response to rigidity gradients using optic ray theory, showing behavior analogous to Snell's law and demonstrating guidance by stiffness variations.

This study uses tiv-AFM to show that in vivo tissue stiffness gradients in Xenopus brain development are driven by differential cell proliferation and guide axon growth.