Design, development, and evaluation of gene therapeutics specific to KSHV-associated diseases
Tomoki Inagaki, Jonna Magdallene Espera, Kang-Hsin Wang, Somayeh Komaki, Sonali Nair, Ryan R. Davis, Ashish Kumar, Ken-ichi Nakajima, Yoshihiro Izumiya
This paper develops a gene therapy vector targeting KSHV-infected cells using AAV8-TR2-OriP-TK, which, when combined with ganciclovir, effectively eradicates KSHV-associated cancers in xenograft models.
Molecular Therapy Oncology · Sep 5, 2025Peer-reviewedMicrobiology