Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response
Itziar Cenzano, Miguel Cócera, Marta Larráyoz, Lorea Campos‐Dopazo, Sonia Sanz, Azari Bantan, Amaia Vilas‐Zornoza, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Diego Alignani, Aitziber López, Ignacio Sancho, Javier Ruiz, Purificación Ripalda‐Cemboráin, Marta Abengozar‐Muela, , Felipe Prósper
This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.
Nature Communications · Jun 23, 2026Peer-reviewedCancer Biology