A Favorable Modifiable Risk Factor Profile Mitigates Polygenic Risk for Alzheimers Disease and Related Dementia
Clayton O. Mansel, Soniya Mishra, Andrew Craver, Sebastian F. Salathe, John P. Thyfault, Julia Anglen Bauer, Diego R Mazzotti, Olivia J. Veatch
This study shows that a favorable lifestyle reduces ADRD risk even in individuals with high polygenic risk, but APOE ε4 genotype remains a strong risk factor.
medRxiv · Jun 2, 2026 · PreprintGenetic & Genomic Medicine