John P. Thyfault

This study shows that Brca1 heterozygosity causes hepatic steatosis in both male and female mice on a high-fat diet, despite sex differences in systemic metabolic outcomes.

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

This study shows that (R,S)-1,3-butanediol improves memory in female tauopathy mice on chow but not on high-fat diets or after long-term use, highlighting sex and diet-dependent cognitive benefits.

This study shows that a favorable lifestyle reduces ADRD risk even in individuals with high polygenic risk, but APOE ε4 genotype remains a strong risk factor.

This study shows that liver-specific HMGCS2 knockout reduces exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

This study shows that estrogen therapy restores synaptic and metabolic proteins in the brain of aged mice after ovariectomy, improving mitochondrial function and synaptic integrity.

This study shows that estrogen receptor α in hepatocytes is necessary for estrogen to enhance mitochondrial respiration and reduce steatosis after ovariectomy.

In 4-month-old APOE targeted-replacement mice, APOE4 remodels the liver proteome sex-dependently; in isogenic iPSC-derived hepatocytes it impairs respiration and raises glycolysis and lipid droplets.

This study shows that overexpressing NAMPT in adipocytes protects against metabolic dysfunction in male obese mice but not females, via improved interorgan communication and extracellular vesicle effects.

This study shows that exercise or donepezil treatment can reduce proteomic changes in sciatic nerves of 5xFAD mice, preserving neuromuscular function before cognitive decline.

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.

This study shows that ketone metabolism is essential for the development and function of the somatosensory nervous system, with loss of ketolysis causing myelination deficits and proprioceptive impairments.

This study maps multi-omic mitochondrial changes across 19 tissues in rats after endurance exercise training, identifying tissue-specific adaptations and disease-related hubs.