Author

Clayton O. Mansel

University of Kansas Medical CenterORCID 0000-0002-0135-7576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:electronic health records· 1 Organism:human· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew CraveriD· 1 shared Diego R MazzottiiD· 1 shared John P. ThyfaultiD· 1 shared Julia Anglen BaueriD· 1 shared Olivia J. VeatchiD· 1 shared Sebastian F. SalatheiD· 1 shared Soniya Mishra· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Andrew CraverORCID

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1 paper

Recent·Most cited

A Favorable Modifiable Risk Factor Profile Mitigates Polygenic Risk for Alzheimers Disease and Related Dementia

Clayton O. Mansel, Soniya Mishra, Andrew Craver, Sebastian F. Salathe, John P. Thyfault, Julia Anglen Bauer, Diego R Mazzotti, Olivia J. Veatch

This study shows that a favorable lifestyle reduces ADRD risk even in individuals with high polygenic risk, but APOE ε4 genotype remains a strong risk factor.

medRxiv · Jun 2, 2026 · PreprintGenetic & Genomic Medicine