Molecular characterization of MRI/CYREN reveals the Ku binding mode and the role of multimerization in stimulating the activity of NHEJ in DNA repair
D. Vu, Kaela Makins, Sonja Knoedlstorfer, Philippe Pelupessy, Ludovic Carlier, Guillaume Bouvignies, Jeremy M. Stark, Mauro Modesti, Fabien Ferrage
This study characterizes MRI/CYREN's structure and function in NHEJ, showing its disordered regions bind Ku80 and multimerization enhances DNA repair efficiency.
bioRxiv · Jul 23, 2026 · PreprintBiophysics