AAV VP1 unique region (VP1u) determines GPR108 dependence for AAV transduction of human airway epithelium and its rescue by Doxorubicin
Siyuan Hao, Ariful Habib, Xiujuan Zhang, Kang Ning, Soo Yuen Park, Shane McFarlin, Çağla Aksu Küz, Donovan Richart, Fang Cheng, Ziying Yan, Jianming Qiu
This study identifies that the AAV2.5T capsid's VP1u region depends on GPR108 for transduction of human airway epithelium, and that doxorubicin enhances transduction by improving nuclear import.
bioRxiv · Jul 10, 2026 · PreprintMicrobiology