Shane McFarlin

TBC1D23-AAVR Interaction Drives Endosome-to-TGN Trafficking Required for rAAV Transduction

This paper identifies TBC1D23 as a host protein that binds AAVR and mediates endosome-to-TGN trafficking required for rAAV transduction.

Identification of Human Transferrin Receptor as an Entry Co-receptor for Parvovirus B19 Infection of Human Erythroid Progenitor Cells

This study identifies human transferrin receptor 1 (hTfR) as a co-receptor for parvovirus B19 (B19V) entry into erythroid progenitor cells, showing that hTfR binding to the viral VP1u protein is critical for viral internalization and replication.

AAV VP1 unique region (VP1u) determines GPR108 dependence for AAV transduction of human airway epithelium and its rescue by Doxorubicin

This study identifies that the AAV2.5T capsid's VP1u region depends on GPR108 for transduction of human airway epithelium, and that doxorubicin enhances transduction by improving nuclear import.

Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors

This study identifies SLC35A1 as a host factor essential for rAAV transduction, showing its role in vector nuclear import across multiple AAV serotypes.