More efficacious drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1
Alison F Feder, Soo-Yon Rhee, Robert W Shafer, Dmitri A Petrov, Pleuni S Pennings
The paper shows that more effective HIV drugs lead to harder selective sweeps in drug resistance evolution, as evidenced by analyzing HIV-1 sequences over time.
bioRxiv · Aug 7, 2015 · PreprintEvolutionary Biology