Alison F. Feder

Duplex sequencing of a Li-Fraumeni family links germline TP53 p.R181H to higher neutral-region mutagenesis and weaker blood TP53 selection, plus recurrent p.R248Q/W hits across proband tissues.

The paper shows HIV can adapt to antibody treatment without reducing genetic diversity, challenging methods that rely on diversity and haplotype signatures to detect resistance.

This study examines HIV escape from two bNAbs in vivo, identifying recurrent mutations and genetic background dependencies in viral resistance.

The paper introduces AMSD, a signature-agnostic metric to detect differences in mutation spectra between groups, showing its effectiveness in identifying carcinogen and ancestry effects.

This paper develops an intra-host eco-evolutionary model of poliovirus under pocapavir treatment, showing that antiviral potency must balance immediate viral suppression with preserving coinfection to prevent resistance.

This paper uses a computational model to show that gene-corrected cells must have strong proliferative advantages to spread in the oral epithelium and that delivering correction to many cells reduces stochastic loss.

This study evaluates tree balance statistics for detecting growth rate heterogeneity in lineage tracing trees of cancer populations, finding J1 performs well while Sackin index is less effective.

The paper shows that more effective HIV drugs lead to harder selective sweeps in drug resistance evolution, as evidenced by analyzing HIV-1 sequences over time.