Author

Sophia L. Wells

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra–Chloé VillaniiD· 1 shared Api ChewcharatiD· 1 shared Astrid WeinsiD· 1 shared Ce GaoiD· 1 shared David E. LeafiD· 1 shared Deepak A. RaoiD· 1 shared Dennis G. MoledinaiD· 1 shared Elad SharoniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alexandra–Chloé VillaniORCID

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1 paper

Recent·Most cited

Spatial Transcriptomics Identify T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis

Qian Qin, Lennard Ostendorf, Sophia L. Wells, Ce Gao, Miles Tran, Firasat M Alikhan, Xiwen Zhang, Api Chewcharat, Robert S Rider, Sean A Prell, Raad B. Chowdhury, Astrid Weins, Sujal I. Shah, Kavita Mistry, Teresa Venezia Bowman, , Shruti Gupta

This study uses spatial transcriptomics to identify CD8+ T cell-driven mechanisms of kidney damage in ICI-AIN, showing increased IFN-γ signaling and proinflammatory myeloid cell activation.

bioRxiv · Oct 31, 2025 · PreprintImmunology