Blunted glucocorticoid responsiveness to stress causes behavioral and biological alterations that lead to posttraumatic stress disorder vulnerability
Silvia Monari, Isabelle Guillot de Suduiraut, Jocelyn Grosse, Olivia Zanoletti, Sophie E. Walker, Michel Soares Mesquita, Tobias Wood, Diana Cash, Simone Astori, Carmen Sandi
This study shows that reduced glucocorticoid responsiveness to stress causes multiple PTSD-related traits in rats, including fear extinction deficits, small hippocampal volume, and REMS disturbances.
Biological Psychiatry · Sep 22, 2023Peer-reviewedNeuroscience