Enhanced extracellular matrix remodeling due to embedded spheroid fluidization
Tao Zhang, Shabeeb Ameen, Sounok Ghosh, Kyungeun Kim, Mrinal Pandey, Brian C. H. Cheung, Minh Tri Ho Thanh, Alison E. Patteson, Mingming Wu, J. M. Schwarz
This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.
New Journal of Physics · Jun 25, 2025Peer-reviewedBiophysics