Tao Zhang

This study identifies VCP inhibition as a therapeutic strategy for RB1-deficient tumors by revealing glutamine-regulated VCP acetylation as a proteostasis vulnerability.

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

The paper proposes a multiscale hypothesis to explain structural differences in brain organoids derived from human versus genetically close non-human primate stem cells, linking chromatin reorganization to delayed cell fate transitions.

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

The paper shows how mechanical forces from epithelial and mesenchymal compartments coordinate cell shape and fate to form tissue architecture during hair follicle development.