Proteome integral solubility alteration assay for monitoring antibody-antigen cell interactions
Weiqi Lu, Susanna L. Lundström, Yaolin Hou, Sourav Mukherjee, Jesper Z. Haeggström, Massimiliano Gaetani, Roman A. Zubarev
The study uses a modified PISA assay to identify TNF as the antigen of infliximab among 8,000 proteins in activated monocytes, demonstrating its utility for antibody-antigen interaction analysis.
bioRxiv · Sep 4, 2025 · PreprintMolecular Biology