Author

Jesper Z. Haeggström

Karolinska InstitutetORCID 0000-0002-1823-5153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. HosseiniiD· 1 shared Federico Pozzani· 1 shared Laura OrellanaiD· 1 shared Massimiliano GaetaniiD· 1 shared Olof RådmarkiD· 1 shared Roman A. ZubareviD· 1 shared Sourav Mukherjee· 1 shared Susanna L. LundströmiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. HosseiniORCID

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2 papers

Recent·Most cited

Structural basis for ATP regulation of human 5-lipoxygenase

Tarvi Teder, Federico Pozzani, Tim Paul Schulte, A. Hosseini, Olof Rådmark, Laura Orellana, Jesper Z. Haeggström

This study presents a cryo-EM structure of human 5-lipoxygenase bound to ATP, revealing how ATP regulates enzyme activity through specific amino acid interactions and conformational changes.

bioRxiv · Nov 26, 2025 · PreprintBiochemistry

Proteome integral solubility alteration assay for monitoring antibody-antigen cell interactions

Weiqi Lu, Susanna L. Lundström, Yaolin Hou, Sourav Mukherjee, Jesper Z. Haeggström, Massimiliano Gaetani, Roman A. Zubarev

The study uses a modified PISA assay to identify TNF as the antigen of infliximab among 8,000 proteins in activated monocytes, demonstrating its utility for antibody-antigen interaction analysis.

bioRxiv · Sep 4, 2025 · PreprintMolecular Biology