Sex-dependent control of renal tubular homeostasis and stress tolerance by KDM6A
Lisa Y. Q. Hong, Sri Nagarjun Batchu, Duc Tin Tran, Madiha Zahra Syeda, Suzanne L. Advani, Youan Liu, Alain Pacis, Evgeniy V. Petrotchenko, Christoph H. Borchers, Darren A. Yuen, Andrew Advani
This study shows that KDM6A deletion in female kidney tubule cells causes fibrosis and metabolic dysfunction, while males are unaffected due to compensatory UTY expression.
bioRxiv · Jul 24, 2026 · PreprintPhysiology