Christoph H. Borchers

PHENOMS analyzes hydrogen-bond networks in molecular dynamics simulations using Rust-accelerated code, achieving significant speedup over Python-based tools and demonstrating its utility with HDX-MS data.

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

This study identifies a mitochondria-to-nucleus kinase signaling pathway that promotes longevity in sod-2 mutants by upregulating innate immunity and cuticle formation genes.

This study shows that endogenous insulin in pancreatic cancer tumors affects tumor growth and systemic metabolism, with differential effects based on diet and mouse sex.

This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.

This study shows that KDM6A deletion in female kidney tubule cells causes fibrosis and metabolic dysfunction, while males are unaffected due to compensatory UTY expression.

This study finds that lithocholic acid levels are lower in stunted and EED children, and it modulates butyrate-producing bacteria growth while inhibiting oral taxa.

This study identifies cancer-driven suppression of muscle stem cell differentiation in cachectic mice through GDF15 and MMP9, revealing a new mechanism of muscle wasting.

This study shows that IRP1 deficiency in mice leads to metabolic changes that protect against metabolic syndrome by altering mitochondrial function and improving insulin sensitivity.

This study combines LiP-MS and molecular dynamics simulations to prioritize KRas G12D inhibitors by analyzing cleavage site protection and binding affinity.

The paper uses HDX-MS and MD simulations to analyze KRas G12D-inhibitor interactions, showing a correlation between binding affinity and structural changes.

SysQuan uses SILAC mouse tissues as internal standards to enable affordable absolute quantitation of the human proteome, improving comparability across studies and laboratories.

This study identifies proteomic changes in the human male olfactory bulb associated with depression, highlighting astrocytic dysfunction and species-specific differences in mouse models.

The paper introduces a method to isolate intact microvessels from frozen tissue and uses multi-omics to characterize the neurovascular unit.

The paper identifies protein biomarkers for spinal cord injury severity and recovery using proteomic analysis of human and porcine samples, showing high predictive accuracy.

The paper develops a mass-spectrometry-based method to detect SARS-CoV-2 virus by identifying the nucleocapsid N protein in nasopharyngeal swabs, showing high sensitivity and simplicity.

This paper reviews affinity-MS technologies for quantitative proteomics, highlighting their specificity and sensitivity in measuring low-abundance proteins in biological fluids.