Alain Pacis

This study identifies a mitochondria-to-nucleus kinase signaling pathway that promotes longevity in sod-2 mutants by upregulating innate immunity and cuticle formation genes.

This study shows that KDM6A deletion in female kidney tubule cells causes fibrosis and metabolic dysfunction, while males are unaffected due to compensatory UTY expression.

This paper identifies Cyrene as a geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila, improving stress resistance and neuroprotection.

This study maps the metabolic complex genetic interaction network of chromosome 4p loss in basal breast cancer to identify targetable vulnerabilities.

This study identifies age-related vacuolation in multi-ciliated cells of the distal mouse oviduct, linked to reduced blood flow and unique cellular identity in the infundibulum and ampulla.

This study shows lithium partially rescues transcriptomic and epigenomic changes in AKAP11 heterozygous knockout neurons, suggesting potential therapeutic relevance for bipolar disorder and schizophrenia.

The paper investigates the evolution of chromosome 4p loss in basal breast cancer, identifying C4orf19 as a novel gene that suppresses proliferation and is part of a kinase module.

The paper introduces EpiVar Browser, a tool for exploring epigenomics data under controlled access, enabling genotype-chromatin phenotype analysis without releasing identifiable information.

The paper uses genome graphs to detect polymorphic mobile elements in active epigenomic states during influenza infection, revealing novel peaks and modifying quantitative trait loci estimates.

The paper shows ancestry-related differences in transcriptional response to influenza are driven by epigenetic variation and genetic control of enhancer activity.

The paper investigates how HIV and antiretroviral therapy affect the transcriptional and epigenetic response of alveolar macrophages to Mycobacterium tuberculosis.

The paper identifies two distinct epithelial cell lineages in the oviduct, spatially separated along the distal-proximal axis, with distinct developmental origins.

The paper investigates how early-life adversity affects epigenetic layers and gene expression in the amygdala, finding associations with immune and small GTPase dysregulation.

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.

The paper shows that gene expression changes precede DNA demethylation in human dendritic cells during infection with Mycobacterium tuberculosis.

This study shows that bacterial infection rapidly alters DNA methylation in human dendritic cells, affecting enhancer elements and gene expression related to immune responses.