Stress triggers global histone synthesis in the liver
Shreenidhi Rajkumar, Lavanya Vumma, Jacinth Naidoo, Min Zhu, Ishrat Durdana, Sri Vidhya Chandrasekar, Caiden J. Golder, Harsh Goar, W. Kiran Kicinski, Rico Gamuyao, Yudong Wei, Hao Zhu, Suraj J. Patel, Joseph M. Ready, Michael Buszczak, Joshua James Gruber
The paper measures histone synthesis rates in vivo and finds that stress induces a surge in hepatocyte nucleosome production uncoupled from DNA replication.
bioRxiv · Sep 23, 2026 · PreprintMolecular Biology