Joseph M. Ready

The paper measures histone synthesis rates in vivo and finds that stress induces a surge in hepatocyte nucleosome production uncoupled from DNA replication.

This study identifies microbiota-derived short-chain fatty acids as key mediators of Candida albicans colonization resistance in the gut.

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

This paper reveals that SINE compounds induce XPO1 degradation via an allosteric mechanism involving ASB8, distinct from molecular glue degraders.

This study identifies new antimalarial compounds targeting PfATP4 through phenotypic screening, showing fast-killing activity and resistance patterns consistent with PfATP4 inhibition.

This paper identifies new drug targets in Schistosoma mansoni using a genome-scale pipeline and discovers a p97 allosteric binding site that could lead to species-selective inhibitors.

The paper identifies NCI-2, a covalent inhibitor of the SARS-CoV-2 NiRAN domain, and presents a structural blueprint for drug design.