The mutational landscape of single neurons and oligodendrocytes reveals evidence of inflammation-associated DNA damage in multiple sclerosis
Allan Motyer, Stacey Jackson, Bicheng Yang, Ivon Harliwong, Wei Tian, Wingin Shiu, Yunchang Shao, Bo Wang, Catriona McLean, Michael Harry Barnett, Trevor John Kilpatrick, Stephen Leslie, Justin P. Rubio
The paper analyzes somatic mutations in neurons and oligodendrocytes from MS patients, finding increased DNA damage linked to inflammation.
bioRxiv · Apr 30, 2022 · PreprintGenomics