Stephen Leslie

The paper tests associations between maternal KIR haplotypes and fetal HLA-C alleles with birth weight in a large sample, finding no significant interactions or replication of previous findings.

The paper introduces an algorithm to efficiently simulate local ancestry tracts from tree sequences, implemented in tskit and tspop.

The paper analyzes somatic mutations in neurons and oligodendrocytes from MS patients, finding increased DNA damage linked to inflammation.

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

MHC*IMP imputes alleles for MHC genes using a reference panel and SNP data, achieving high accuracy in allele prediction.

The paper investigates the association between LILRB2-HLA-B interaction strength and psoriasis susceptibility using GWAS data, finding an inverse relationship with risk.

This study identifies genetic subsets of EGPA associated with asthma and eosinophil levels, revealing two distinct clinical and genetic syndromes.

This paper develops a Bayesian framework to analyze genetic associations with healthcare phenotypes in the UK Biobank, identifying over 2,000 diagnostic term associations and novel immune-mediated disease links.

Quality-controlled genotypes for 488,377 UK Biobank participants at 805,426 markers, imputed to ~96 million variants, plus ancestry PCs, kinship (30.3% have close relatives enrolled) and HLA calls.

The paper evaluates HLA imputation methods using a multi-ethnic panel, introduces a new method HLA*IMP:03, and shows it achieves high accuracy without requiring probability thresholds.