Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation
Margaritis Voliotis, Xiao Feng Li, Ross De Burgh, Geffen Lass, Stafford L Lightman, Kevin T. O’Byrne, Krasimira Tsaneva-Atanasova
The paper develops a mathematical model of the GnRH pulse generator, showing that increasing basal activity leads to pulsatile luteinizing hormone release and frequency changes through feedback mechanisms.
bioRxiv · Dec 11, 2018 · PreprintPhysiology