Kevin T. O’Byrne

Integrating Models to Decode the GnRH Pulse Generator

This paper uses computational modeling to integrate experimental data and decode the dynamics of the GnRH pulse generator, focusing on the KNDy network and its modulation by external factors.

GABA Neurons in the Amygdala play a central Role in Urocortin-3-Mediated Stress Suppression of Reproduction

This study identifies two anti-correlated GABA subpopulations in the MePD that mediate UCN3-mediated stress suppression of reproduction through mutual inhibition and downstream LH regulation.

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

The paper shows estradiol changes ion channel activity in kisspeptin neurons, altering their firing patterns and affecting GnRH release through glutamatergic signaling.

Neuronal Network Dynamics in the Posterodorsal Amygdala: Shaping Reproductive Hormone Pulsatility

This study uses in-silico modeling to explore how MePD neuronal dynamics influence GnRH pulse generator activity and stress-related regulation.

GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice

The paper investigates how kisspeptin neurons in the medial amygdala modulate GnRH pulse frequency through GABA and glutamate neurotransmission in female mice.

Role of posterodorsal medial amygdala urocortin-3 in pubertal timing in female mice

This study shows that psychosocial stress delays puberty and increases anxiety in female mice by affecting Urocortin3 neurons in the medial amygdala.

Modulation of pulsatile GnRH dynamics across the ovarian cycle: the role of glutamatergic transmission in the arcuate kisspeptin network.

The paper investigates how glutamatergic transmission modulates GnRH pulsatility in the arcuate kisspeptin network across the estrous cycle using optogenetics and mathematical modeling.

Dynamic hormone control of stress and fertility

This paper models the HPA and HPG axes as coupled oscillators to understand how stress perturbations affect fertility and hormone dynamics.

Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation

The paper develops a mathematical model of the GnRH pulse generator, showing that increasing basal activity leads to pulsatile luteinizing hormone release and frequency changes through feedback mechanisms.