Xiao Feng Li

This paper uses computational modeling to integrate experimental data and decode the dynamics of the GnRH pulse generator, focusing on the KNDy network and its modulation by external factors.

The paper shows estradiol changes ion channel activity in kisspeptin neurons, altering their firing patterns and affecting GnRH release through glutamatergic signaling.

This study uses in-silico modeling to explore how MePD neuronal dynamics influence GnRH pulse generator activity and stress-related regulation.

The paper investigates how kisspeptin neurons in the medial amygdala modulate GnRH pulse frequency through GABA and glutamate neurotransmission in female mice.

The paper investigates how glutamatergic transmission modulates GnRH pulsatility in the arcuate kisspeptin network across the estrous cycle using optogenetics and mathematical modeling.

This paper models the HPA and HPG axes as coupled oscillators to understand how stress perturbations affect fertility and hormone dynamics.

The paper shows that optogenetic stimulation of MePD kisspeptin neurons in female mice increases LH pulse frequency, suggesting their role in regulating the GnRH pulse generator.

The paper develops a mathematical model of the GnRH pulse generator, showing that increasing basal activity leads to pulsatile luteinizing hormone release and frequency changes through feedback mechanisms.