Ross de Burgh

This study identifies two anti-correlated GABA subpopulations in the MePD that mediate UCN3-mediated stress suppression of reproduction through mutual inhibition and downstream LH regulation.

The paper investigates how kisspeptin neurons in the medial amygdala modulate GnRH pulse frequency through GABA and glutamate neurotransmission in female mice.

The paper shows that optogenetic stimulation of MePD kisspeptin neurons in female mice increases LH pulse frequency, suggesting their role in regulating the GnRH pulse generator.

The paper develops a mathematical model of the GnRH pulse generator, showing that increasing basal activity leads to pulsatile luteinizing hormone release and frequency changes through feedback mechanisms.