Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA
Guillaume A. Petit, Biswarajan Mohanty, Róisín M. McMahon, Stefan Nebl, David H. Hilko, Karyn L. Wilde, Martin J. Scanlon, Jennifer L. Martin, Maria A. Halili
This paper identifies two drug-like fragments that bind to a cryptic pocket in B. pseudomallei DsbA, showing weak binding but potential for optimization.
Acta Crystallographica Section D Structural Biology · Dec 22, 2021Peer-reviewedMolecular Biology