PEG-free, Triphosphate-Stabilized LNPs Enable Potent RNA Delivery
Gholan M. Hamraz, Mario Alberto Saucedo‐Espinosa, Kerstin C. Walzer, Florian Frohns, Elfi Katrin Schlohsarczyk, Jakob Käppler, Björn Fröhlich, Stephan Schmidt, Carsten Hopf, Steffen Panzner
This paper introduces PEG-free lipid nanoparticles stabilized with sodium triphosphate for RNA delivery, showing improved early expression and comparable safety in mice.
bioRxiv · Dec 23, 2025 · PreprintBiochemistry