Lung-targeted cytokine-coding RNA-lipoplexes induce T and NK cell-mediated anti-tumor immune response
Ayline Kübler, Sophie-Christin Linkenbach, Fulvia Vascotto, Elif Diken, Özlem Akilli‐Öztürk, Eliana Stanganello, Aniello Federico, Sina Fellermeier-Kopf, Alexander Muik, Friederike Gieseke, M Suchan, Ferdia Bates, Kaushik Thanki, Hossam Hefesha, Isaac Hernan Esparza Borquez, , Uğur Şahin
This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.
bioRxiv · May 11, 2026 · PreprintImmunology