Inhibition of CDK7, CDK9 or CDK12 affects phosphorylation of human SPT5.
Shona Murphy, Stephanie Barker, Girish R. Mali, Joey Riepsaame, Sophie Sheldon, Isabella Maudlin
The paper shows that CDK7, CDK9, and CDK12 phosphorylate SPT5, with CDK9 having the strongest effect on SPT5 phosphorylation and PAF1C interaction.
bioRxiv · Oct 28, 2026 · PreprintMolecular Biology