Joey Riepsaame

Inhibition of CDK7, CDK9 or CDK12 affects phosphorylation of human SPT5.

The paper shows that CDK7, CDK9, and CDK12 phosphorylate SPT5, with CDK9 having the strongest effect on SPT5 phosphorylation and PAF1C interaction.

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

This study uses cerebellar organoids to model FOXP2 expression in early human cerebellar development and identifies its targets and associated neurodevelopmental vulnerabilities.

Guide RNA library representation results in gene essentiality prediction bias in genome-wide CRISPR screens

This study shows that gRNA library representation bias affects gene essentiality predictions in CRISPR screens, with library choice being the most significant factor.

Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis

This study identifies cholesteryl ester-enriched lipid droplets as critical host components required for flavivirus infection and shows their role in viral morphogenesis.

PTCH1 mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis

This study uses human iPSC-derived cerebellar organoids to investigate how PTCH1 mutations affect neural development and early medulloblastoma pathways.

Selective roles of vertebrate PCF11 in premature and full-length transcript termination

This study shows PCF11 is critical for vertebrate development by promoting transcription termination and preventing transcriptional interference.