Shona Murphy

The paper shows that CDK7, CDK9, and CDK12 phosphorylate SPT5, with CDK9 having the strongest effect on SPT5 phosphorylation and PAF1C interaction.

This study shows that Madrasin and Isoginkgetin inhibit transcription before affecting splicing, suggesting they are not primary splicing inhibitors.

This study shows that SF3B1 inhibition disrupts P-TEFb recruitment to chromatin through multiple mechanisms involving nuclear export and degradation of splicing factors.

This study shows that pro-inflammatory polarization and CRC cell co-culture alter 3UTR-APA and IPA in primary human macrophages, with SRSF12 playing a key role.

The paper investigates how cytoplasmic mRNA levels are influenced by chromatin retention and RNA stability, finding that poor RNA processing leads to increased chromatin retention and shorter half-life.

This study shows CDK9 and PP2A regulate RNA polymerase II transcription termination and RNA maturation by modulating polyadenylation and splicing factors.

This study identifies ICP22 as a viral repressor of cellular RNA polymerase II transcription elongation by interacting with elongation factors, and suggests VP16 may compete with ICP22 for these factors.

This study shows that the RS domain of CFIm68 is critical for selecting between alternative polyadenylation sites in human cells.