Repeated SARS-CoV-2 Antigenic Exposures from Prior Vaccinations and Infections Demonstrate Limits of Antibody Durability and Breadth Against Newer Variants
Wei Wang, Emilie Goguet, Sabrina Lusvarghi, Stephanie Paz, Leeza Shrestha, Russell A. Vassell, Simon D. Pollett, Edward E.S. Mitre, Carol D. Weiss
This study assesses how repeated antigenic exposures from vaccination and infection affect antibody responses to newer SARS-CoV-2 variants, finding waning neutralizing titers over time and limited breadth against emerging variants.
bioRxiv · Apr 16, 2026 · PreprintMicrobiology