Wei Wang

This study assesses how repeated antigenic exposures from vaccination and infection affect antibody responses to newer SARS-CoV-2 variants, finding waning neutralizing titers over time and limited breadth against emerging variants.

This study investigates the entry mechanisms of seasonal human coronaviruses NL63, 229E, and HKU1 using pseudoviruses and cell lines expressing ACE2, APN, or TMPRSS2, revealing endocytosis as the entry route and specific protease and receptor requirements.

The paper uses hamster sera to map antigenic differences among SARS-CoV-2 variants, showing JN.1 has significant antigenic divergence from XBB.1.5.