ALKALs are in vivo ligands for ALK family Receptor Tyrosine Kinases in the neural crest and derived cells.
Andrey Fadeev, Patricia Mendoza-García, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio C. Serluca, Ajeet Pratap Singh, Christiane Nüsslein‐Volhard, Ruth Helen Palmer
The paper demonstrates that ALKALs activate ALK/LTK family receptors and are involved in neural crest development using zebrafish and Drosophila models.
Proceedings of the National Academy of Sciences · Jan 9, 2018Peer-reviewedDevelopmental Biology