Structural and molecular basis of FAN1 defects in promoting Huntington's disease
F. Li, Ashutosh S. Phadte, Mayuri Bhatia, Sarah Barndt, Anthony R. Monte Carlo, Chun-Feng David Hou, Rong Yang, Stephen B. Strock, Anna Pluciennik
This study identifies how the Arg507His mutation in FAN1 impairs its interaction with PCNA and DNA cleavage, accelerating Huntington's disease onset.
Nature Communications · May 14, 2025Peer-reviewedBiochemistry