ACKR1-expressing venous endothelial cells establish a pro-fibrotic niche in pulmonary fibrosis
Konstantinos Kontodimas, Ahmed Raslan, Benjamin Spira, Uyen Chu, Arun Narota, Hiroki Murata, Yasuaki Hashimoto, Roberto F. Nicosia, Xintao Qiu, Steven Huang, Maria E. Trojanowska, Xaralabos Varelas, Giovanni Ligresti
The paper identifies ACKR1-expressing venous endothelial cells as key drivers of fibrosis in IPF and shows ACKR1 inhibition reduces fibrosis in vivo.
bioRxiv · Aug 3, 2026 · PreprintMolecular Biology